Aztreonam
Azactam ® - Renal dosing |
| Usual
Dosing (Adults) |
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[Mild infection] (i.e. UTI): 500mg to 1 gram IV q8-12h.
[Usual dose]: 1-2 grams IV q8-12h.
[Severe/life threatening infection]: 2 grams IV q6-8h.
[Maximum dose]: 8 grams/day.
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| Renal
Dosing |
IV:
[CRCL >30 ml/min]: no change.
[10-30 ml/min]: Loading dose: 1-2 grams x 1, then give 50% of the usual dose (e.g. 0.5 – 1 gm) q6-12h.
[<10 ml/min]: 1–2 grams x 1, then 25% of usual dose (e.g. 250-500 mg) q6-12 hours.
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| Hemodialysis |
Hemodialysis:
1 – 2 grams x 1, then 25% of usual dose q6-12h. (e.g., 250-500 mg q6-12 hours).
For serious or life-threatening infections, give an additional 125mg after each hemodialysis session (1/8th of the usual dose).
PD:
1 – 2 grams x 1, then 25% of usual dose q6-12h. (e.g., 250-500 mg q6-12 hours).
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