Aztreonam
Azactam ® |
| Usual
Diluents |
| D5W, NS |
| Standard
Dilutions [Amount of drug]
[Infusion volume] [Infusion rate] |
[0 - 1 gram/ 50 ml]
[30 min]
[Over 1 gram/ 100 ml] [60 min]
|
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| Stability
/ Miscellaneous |
EXP: 1 Day
(RT);
7 Days (REF). Label: Refrigerate.
May
be given IM (preparation): 500mg/1.5 ml; 1 gram/ 3 ml; 2
grams/6 ml H20, BS-H20, NS. Greater volumes may be used.
Usually
restricted to one of the following: (1) Gram negative infections
(primarily Pseudomonas) in penicillin allergic patients. (2) Patients at
increased risk of aminoglycoside toxicity (poor renal function or
rapidly changing renal function) with a gram negative infection. ***Lacks
anaerobe coverage***
Dosing: Mild
infection (i.e. UTI): 500mg to 1g ivpb q8-12h. Usual dose: 1-2g ivpb
q8-12h. Severe or life threatening: 2g ivpb q6-8h. Max 8g/day.
Renal Dosing:>30/ no change || 10-30/ 50% of usual dose q6-8h
|| <10/ 25% of usual dose q6-8h || HD/PD: see <10 guidelines. (HD:
500mg AD) Give loading dose of 1-2g before starting regimens above. |
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