Anti-hypertensive
Combinations
|
|
|
| ACE
inhibitors & diuretics <TOP> |
Benazepril
&
HCTZ
(Lotensin HCT ®) |
Benazepril (HTN) range: 10-80 mg qd (Initial: 10mg po qd).
HCTZ (Range): 12.5-50 mg per day. Lotensin HCT 10/12.5 or
Lotensin HCT 20/12.5. The HCTZ dose should generally
not be increased until 2-3 weeks have elapsed. Patients whose blood
pressures are adequately controlled with 25 mg of daily HCTZ, but
who experience significant potassium loss with this regimen, may
achieve similar blood-pressure control without electrolyte
disturbance if they are switched to Lotensin HCT 5/6.25.
Supplied: (5 mg/6.25 mg, 10 mg/12.5 mg, 20 mg/12.5 mg, 20 mg/25 mg) |
Captopril
& HCTZ
(Capozide ®) |
Adult (usual) Hypertension (HTN): initial, 1 tab (captopril 25 mg/HCTZ
15 mg) orally once daily. HTN: titration, allow 6-8 wk to achieve
optimum antihypertensive effect - may administer daily dose in
divided doses. HTN: maximum dose: 150 mg captopril and 50 mg HCTZ per day.
Supplied: (25 mg/15 mg, 25 mg/25 mg, 50 mg/15 mg, 50 mg/25 mg) |
Enalapril
& HCTZ
(Vaseretic ®) | Enalapril
(Usual range): 10 to 40 mg per day administered in a single or two divided
dose. HCTZ (range):
12.5 to 50 mg daily. A
patient whose blood pressure is not adequately controlled with either
enalapril or HCTZ monotherapy may be given Vaseretic 5-12.5 or Vaseretic
10-25. The HCTZ dose should generally not be increased until 2-3
weeks have elapsed. In general, patients do not require doses in excess of
20 mg of enalapril or 50 mg of HCTZ. The daily dosage should not exceed four
tablets of Vaseretic 5-12.5 or two tablets of Vaseretic 10-25.
Supplied:
(5 mg/12.5 mg, 10 mg/25 mg) |
Lisinopril & HCTZ
(Prinzide ®)
(Zestoretic ®) | Hypertension
- Initial dose: 10/12.5 or 20/12.5. Further increases of
either or both components could depend on clinical response. The HCTZ dose
should generally not be increased until 2-3 weeks have elapsed.
Maximum dose: 80/50 mg orally once
daily. Patients
whose blood pressures are adequately controlled with 25 mg of daily HCTZ,
but who experience significant potassium loss with this regimen, may achieve
similar or greater blood pressure control with less potassium loss if they
are switched to 10/12.5. Dosage higher than lisinopril 80 mg and
HCTZ 50 mg should not be used.
Supplied: (10 mg/12.5 mg, 20 mg/12.5 mg, 20 mg/25 mg) |
Moexipril
& HCTZ
(Uniretic ®) | Moexipril
(range) 7.5 to 30 mg daily- administered in a single or two divided
doses. HCTZ (range):
12.5 to 50 mg daily. Initial dose: (7.5 mg
/12.5 mg) or (15 mg /12.5 mg) or (15 mg /25
mg) one hour before a meal. Titrate: q2-3 weeks. Total daily
doses above 30 mg /50 mg a day have not been studied in hypertensive
patients. Patients whose blood pressures are adequately controlled
with 25 mg of HCTZ daily, but who experience significant potassium
loss with this regimen, may achieve blood pressure control without
electrolyte disturbance if they are switched to moexipril 3.75 mg/HCTZ
6.25 mg (one-half 7.5 mg /12.5 mg tablet). For patients who
experience an excessive reduction in blood pressure with 7.5
mg /12.5 mg, the physician may consider prescribing moexipril 3.75
mg/HCTZ 6.25 mg. Supplied: (7.5 mg/12.5 mg, 15mg/12.5
mg, 15 mg/25 mg) |
| Angiotensin-II
receptor antagonists & diuretics <TOP> |
Losartan
&
HCTZ
(Hyzaar ®) |
Adult (usual) Hypertension (HTN): initial, 1 tab (50 mg losartan/12.5
mg HCTZ) po qd. HTN: titration, allow 3 wk to achieve optimum
antihypertensive effect. HTN: titrate to maintenance, may
increase to MAX dose of 100/50 mg orally once daily.
Supplied: (50
mg/12.5 mg, 100 mg/25 mg) |
Valsartan
&
HCTZ
(Diovan HCT ®) |
Adult (usual) Hypertension: initial, 12.5 HCTZ/80 mg valsartan
orally once daily. Hypertension: maintenance 12.5/80 mg to
25/160
mg po qd. Titrate at intervals of 3-4 wekks. MAX 25/160 mg daily.
Supplied: (80 mg/12.5 mg, 160 mg/12.5 mg, 160mg/25 mg) |
| Beta
blockers & diuretics <TOP> |
Atenolol
&
chlorthalidone
(Tenoretic®) | Dosage,
Adult (usual): Hypertension (HTN): initial, 1 tab (50/25 mg) po qd.
HTN: titration, allow 1-2 wk to achieve optimum antihypertensive
effect. HTN: maintenance, may increase to 1 tab (100/25 mg) orally once daily.
Supplied: (50 mg/25 mg, 100 mg/25 mg) |
Bisoprolol
&
HCTZ
(Ziac®) | Hypertension:
initial, 1 tab (2.5/6.25 mg) orally once daily. Titration - allow
1-2 wk to achieve optimum antihypertensive effect. May increase to
MAX dose of 20/12.5 mg orally once daily.
Supplied: (2.5 mg/6.25
mg, 5 mg/6.25 mg, 10 mg/6.5 mg) |
Metoprolol
& HCTZ
(Lopressor HCT®) |
[ HCTZ (range): 12.5 to 50 mg per day. The usual initial dosage of
Lopressor is 100 mg daily in single or divided doses. The effective dosage range is 100 to 450 mg per day.
]
The following dosage schedule may be used to administer from 100 to
200 mg of Lopressor per day and from 25 to 50 mg of HCTZ per day:
Lopressor HCT Dosage Tablets of 50/25 - 2 tablets per
day in single or divided doses. Tablets of 100/25 - 1 to
2 tablets per day in single or divided doses. Tablets of
100/50 - 1 tablet per day in single or divided doses.
Dosing regimens that exceed 50 mg of HCTZ per day are not
recommended.
Supplied: (50 mg/25 mg, 100 mg/25
mg, 100 mg/50 mg) |
Nadolol
&
bendroflumethazide
(Corzide ®) | Initial
dose: 40 mg/5 mg tablet once daily. When the antihypertensive
response is not satisfactory, the dose may be increased by
administering the 80 mg/5 mg tablet once daily. When
necessary, another antihypertensive agent may be added gradually
beginning with 50 percent of the usual recommended starting dose to
avoid an excessive fall in blood pressure.
Supplied: (40 mg/5 mg, 80 mg/5 mg) |
Propranolol
& HCTZ
(Inderide ®) |
HCTZ (range): 12.5 to 50 mg per day. The initial dose of
propranolol is 80 mg daily. The usual effective dose
when used alone is 160 to 480 mg per day. One Inderide tablet
twice daily can be used to administer up to 160 mg of propranolol
and 50 mg of HCTZ. For doses of propranolol greater than 160
mg the combination products are not appropriate, because their use
would lead to an excessive dose of the thiazide component.
Supplied: (40 mg/25 mg, 80 mg/25 mg).
(Inderide LA ®) :
(80
mg/50 mg, 120 mg/50 mg, 160 mg/50 mg) |
Timolol
& HCTZ
(Timolide ®) | Initial
dose (HTN): 1 tablet twice a
day or 2 tablets once a day. HCTZ (range): 12.5 to 50 mg per
day when used alone. If the antihypertensive response is not
satisfactory, another nondiuretic antihypertensive agent may be
added.
Supplied: (10 mg/25 mg) |
| Calcium
channel blockers & ACE inhibitors <TOP> |
Amlodipine
&
benazepril
(Lotrel ®) |
Adult (usual)- Hypertension: initial 2.5/10 mg orally once
daily - may increase to 5/10 mg or 5/20 mg orally once daily.
Amlodipine is an effective treatment of hypertension in once-daily
doses of 2.5-10 mg while benazepril is effective in doses of 10-80
mg. In clinical trials of amlodipine/benazepril combination therapy
using amlodipine doses of 2.5-10 mg and benazepril doses of 10-20
mg, the antihypertensive effects increased with increasing dose of
amlodipine in all patient groups, and the effects increased with
increasing dose of benazepril in nonblack groups.
Supplied:
(2.5 mg/10 mg, 5 mg/10 mg, 5 mg/20 mg) |
Felodipine
&
enalapril
(Lexxel ®) | Adult
(usual) Hypertension: initial, 5mg/5mg tab po qd, may titrate to two
5mg/5mg tab po qd, then four 5mg/2.5 mg tab po qd. Supplied:
(5mg/2.5 mg, 5 mg/5 mg) |
Verapamil
&
trandolapril
(Tarka ®) | Adult
(usual) - 1 tablet po qd. Hypertension: 1-4
mg trandolapril/120-480 mg verapamil po qd or in 2 divided doses.
The recommended usual dosage range of trandolapril for hypertension
is 1 to 4 mg per day administered in a single dose or two divided
doses. The recommended usual dosage range of Isoptin-SR for
hypertension is 120 to 480 mg per day administered in a single dose
or two divided doses. Supplied: (180 mg/2 mg, 240 mg/1
mg, 240 mg/2 mg, 240 mg/4 mg). |
| Diuretic
combinations / Other <TOP> |
Amiloride
& HCTZ
(Moduretic ®) | Give
with food. The usual starting dosage is 1 tablet a day.
The dosage may be increased to 2 tablets a day, if necessary. More
than 2 tablets of Moduretic daily usually are not needed and there
is no controlled experience with such doses. HCTZ (range): 12.5 to 50 mg per
day. Supplied: (5 mg/50 mg) |
Spironolactone
&
HCTZ
(Aldactazide ®) | CHF, hepatic cirrhosis, or
nephrotic syndrome: The usual maintenance dose of Aldactazide is
100 mg each of spironolactone and HCTZ daily, administered in a
single dose or in divided doses, but may range from 25 mg to 200 mg
of each component daily depending on the response to the initial
titration. Hypertension: many patients will be found to have an optimal response
to 50 mg to 100 mg each of spironolactone and HCTZ daily, given in a
single dose or in divided doses. Supplied: (25 mg/50 mg, 50
mg/50 mg) |
Triamterene
&
HCTZ
(Dyazide ®, Maxzide ®) | Adult
(usual) Hypertension (HTN): initial, 1 tab/cap (25 mg HCTZ/37.5
mg triamterene) po qd. HTN: titration, allow 2-3 wk to
achieve optimum antihypertensive effect. HTN: titrate to
maintenance, may increase to maximum dose of 50/75 mg po qd. Supplied:
(37.5 mg/25 mg capsule and tablet, 75 mg/50 mg tablet) |
Clonidine
&
chlorthalidone
(Combipres ®) | Adult
(usual) Hypertension: 15 mg/0.1 mg, 15 mg/0.2 mg, or 15 mg/0.3 mg po
qd - bid. maximum dose of 30 mg/0.6 mg per day. Supplied: (0.1 mg/15
mg, 0.2 mg/15 mg, 0.3 mg/15 mg) |
Hydralazine
&
HCTZ
(Apresazide ®) |
Usual Dosage: One capsule twice daily. Supplied: (25
mg/25 mg, 50 mg/50 mg, 100 mg/50 mg) |
Methyldopa
&
HCTZ
(Aldoril ®) | Usual starting
dose: (250 mg/15 mg) two or
three times a day or one tablet of (250 mg/25 mg) - two times a day.
Alternatively, one tablet of 500 mg/30 mg or 500 mg/50
mg once daily
may be used. HCTZ (range): 12.5 to 50 mg per
day. methyldopa daily range: 500 mg to 2 g. The maximum recommended daily dose of
methyldopa is 3 g.
Supplied:
(250 mg/15 mg, 250 mg/25 mg, 500 mg/30 mg, 500 mg/50 mg) |
Prazosin
&
polythiazide
(Minizide ®) | Usual
- Adults: Oral: 1
capsule 2-3 times/day.
Supplied: (1 mg/0.5 mg, 2 mg/0.5 mg, 5
mg/0.5 mg) |
