 |
Antidepressants (Adult dosing)
 |
|
Approximate equivalent dosages of SSRIs: citalopram 20mg escitalopram 5 mg fluoxetine 20mg paroxetine 20mg sertraline 50mg |
amitriptyline (Elavil ®): |
Class: Tricyclic - Tertiary Amine |
|
Dosing (Adults): Depression: Initially, 25-100 mg orally at bedtime or give in divided doses. Gradually increase to usual effective dose of 50-300mg/day. Chronic pain (adjunct): Initially, 25 mg at bedtime - may increase as tolerated to 100 mg/day. Migraine prophylaxis: Oral: Initial: 10-25 mg at bedtime; usual dose: 150 mg; reported dosing ranges: 10-400 mg/day. Supplied: Tablet: 10 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg |
buproprion ( Wellbutrin ® / Zyban ® ) |
Class: Aminoketone |
|
Dosing (Adults): Depression: Immediate release:
Initially, 100mg orally twice daily, after 4-7 days may increase to 100
mg orally 3 times daily. Usual effective dose: 300-450mg per day.
Maximum: 150mg/dose and 450 mg/day. (Sustained release): Initially, 150mg orally once daily, after 4-7 days, may increase to 150mg twice a day. Maximum 400mg/day. (Zyban - Smoking cessation): start 150mg orally every morning for 3 days, then increase to 150mg orally twice a day for 7 to 12 weeks. Maximum dose: 150 mg orally twice daily. |
citalopram (Celexa ®): |
Class: Selective serotonin reuptake inhibitor (SSRI) |
| Dosing (Adults): Initially, 20 mg orally once daily, generally with an increase to 40 mg/day. Usual maximum: 40 mg/day. Dose increases should occur in 20 mg increments at intervals of no less than 1 week. |
desipramine (Norpramin ®): |
Class: Tricyclic - Secondary Amine |
|
Dosing (Adults): Initially, 25 mg orally once daily or
divided doses. Gradually increase to usual effective dose: 100-300 mg/day. |
doxepin (Sinequan ®): |
Class: Tricyclic - Tertiary Amine |
| Dosing (Adults): Initially, 25 mg orally at bedtime. Usual effective dose: 75-300mg/day. |
duloxetine (Cymbalta ® ) |
Class: Norephinephrine / serotonin reuptake inhibitor |
|
Dosing (Adults): Depression: Initially 40-60 mg qd or (20 - 30 mg bid). Maximum dose: 60 mg/day Diabetic neuropathy: 60 mg orally once daily. Lower initial doses may be considered in patients where tolerability is a concern and/or renal impairment is present. Renal dosing: [CRCL 30-50 ml/min]: Lower initial doses may be considered with titration guided by response and tolerability. [< 30 ml/min]: Not recommended. Supplied: 20 mg, 30 mg, 60 mg capsule. |
escitalopram (Lexapro ® ) : |
Class: Selective serotonin reuptake inhibitor (SSRI) |
|
Dosing (Adults): Depression, GAD: Initially, 10mg
po qd (dose may be increased to 20 mg/day after at least 1 week).
Max: 20mg po qd. [Supplied: 5, 10, 20 mg tabs] |
fluoxetine (Prozac® ) : |
Class: Selective serotonin reuptake inhibitor (SSRI) |
|
Dosing (Adults): Depression, OCD, PMDD, bulimia:
Initially, 20mg orally every morning - may increase after several weeks
by 20 mg/day increments. Usual effective dose: 20-40mg/day. Maximum:
80mg/day. Obsessive compulsive disorder (OCD): 40-80 mg/day. PMDD: 20 mg/day continuously, or 20 mg/day starting 14 days prior to menstruation and through first full day of menses (repeat with each cycle). Panic disorder: Initially, 10 mg/day. After 1 week, increase to 20 mg/day. May increase after several weeks. Doses >60 mg/day have not been evaluated. [Supplied: 10, 20 mg, 40mg capsule. Long-acting delayed release capsule: 90 mg] |
fluvoxamine (Luvox ®): |
Class: Selective serotonin reuptake inhibitor (SSRI) |
| Dosing (Adults): OCD: Initially, 50 mg orally at bedtime, usual effective: 100-300 mg/day divided into 2 doses. Maximum: 300mg/day. |
imipramine (Tofranil ®): |
Class: Tricyclic - Tertiary Amine |
| Dosing (Adults): Initially, 25 mg orally at bedtime, increase gradually to usual effective dose 50-300 mg/day. |
mirtazapine (Remeron ®): |
Class: Tetracyclic |
|
Dosing (Adults): Depression: Initially, 15 mg orally at
bedtime. Usual effective dose: 15-45 mg/day. (Dose increases made no
more frequently than every 1-2 weeks. ) Use: May be particularly helpful in depressed patients with insomnia due to its sedative properties. MOA: antagonizes presynaptic alpha-2 receptors leading to a significant increase in noradrenergic neurotransmission. Also increases serotonin release (not a reuptake inhibitor). Supplied: 15 mg, 30 mg, 45 mg tablet. Orally-disintegrating tablet: 15 mg, 30 mg, 45 mg. |
nefazodone (Serzone ®): |
Class: Phenylpiperazine |
|
Dosing (Adults): Depression: Initially, 100mg orally
twice daily. Usual effective dose: 150-300mg orally twice daily.
Maximum: 600 mg/day. [Supplied: 50 mg, 100 mg, 150 mg, 200 mg, 250 mg tablet.] |
nortriptyline (Pamelor ®): |
Class: Tricyclic - Secondary Amine |
|
Dosing (Adults): Initially, 25mg orally 1 to 4 times
daily. Usual effective dose: 50-150 mg/day. |
paroxetine (Paxil ®): |
Class: Selective serotonin reuptake inhibitor (SSRI) |
|
Dosing (Adults): Depression: Initially, 20 mg orally every morning. Usual effective dose: 20-50 mg/day. Maximum: 50mg/day. (Controlled release tablet - Paxil CR): Initially, 25 mg once daily. Increase if needed by 12.5 mg/day increments at intervals of at least 1 week. Maximum dose: 62.5 mg/day. OCD / Panic attacks: Initially, 10-20mg/day. Increase if needed by 10 mg/day increments at intervals of at least 1 week. Usual effective dose: 10-60 mg/day. Recommended dose: 40 mg/day. Maximum: 60 mg/day. (Controlled release tablet - Paxil CR): Panic attacks: Initially,12.5 mg once daily. Increase if needed by 12.5 mg/day at intervals of at least 1 week. maximum dose: 75 mg/day. GAD: Initially, 20 mg once daily every morning. If dose is increased, adjust in increments of 10 mg/day at 1 week intervals. PMDD: (Controlled release tablet - Paxil CR): Initially, 12.5 mg once daily in the morning. May be increased to 25 mg/day. Dosing changes should occur at intervals of at least 1 week. May be given daily throughout the menstrual cycle or limited to the luteal phase. PTSD: Initially, 20 mg orally every morning. Usual effective dose: 20-50 mg/day. Maximum: 50mg/day. Supplied: 10 mg, 20 mg, 30 mg, 40 mg tablet. Controlled release tablet: 12.5 mg, 25 mg, 37.5 mg. |
sertraline (Zoloft ®): |
Class: Selective serotonin reuptake inhibitor (SSRI) |
|
Dosing (Adults): Depression / OCD: Initially, 50 mg orally once daily. Usual effective dose: 50-200 mg/day. May increase daily dose, at intervals of not less than 1 week. Maximum: 200 mg/day. Panic attacks: Initially, 25mg orally once daily. Maximum: 200 mg/day. PMDD: Usual dose: 50 mg orally once daily throughout menstrual cycle or limited to the luteal phase of menstrual cycle. , depending on physician assessment. May titrate up to 100 - 150mg if poor response. Supplied: 25 mg, 50 mg, 100 mg tablet. Oral concentrate: 20 mg/ml (60 ml.) |
trazodone (Desyrel ®): |
Class: Triazolopyridine |
|
Dosing (Adults): Depression: Initially, 50-150
mg/day orally in divided doses (may increase by 50 mg/day every 3-7
days). Usual effective dose: 400-600 mg/day in divided doses. Maximum:
600 mg/day. Supplied: 50 mg, 100 mg, 150 mg, 300 mg tablet. |
venlafaxine (Effexor ®) |
Class: Norephinephrine / serotonin reuptake inhibitor |
|
Phenethylamine (Non-tricyclic). (Potent inhibitor of serotonin and
norepinephrine reuptake + weak inhibitor of dopamine reuptake. ) Dosing (Adults): Depression: ( Immediate-release tablets): Initially, 75 mg/day divided in 2 to 3 doses (take with food). Dose may be increased in 75 mg/day increments at intervals of at least 4 days. Usual effective dose: 150-225 mg/day. Maximum: 375 mg/day. ( Extended-release capsules): 37.5 to 75 mg orally once daily. Dose may be increased in 75 mg/day increments at intervals of at least 4 days. Maximum: 225 mg/day. GAD, social anxiety disorder: ( Extended-release capsules): 37.5 to 75 mg orally once daily. Dose may be increased in 75 mg/day increments at intervals of at least 4 days. Maximum: 225 mg/day. Supplied: 25 mg, 37.5 mg, 50 mg, 75 mg, 100 mg tablet. 37.5 mg, 75 mg, 150 mg extended release capsule. |
Disclaimer |
|
Listed dosages are for - Adult patients ONLY. PLEASE READ THE
DISCLAIMER CAREFULLY BEFORE
ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE
TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.
GlobalRPH does not directly or indirectly practice medicine or provide
medical services and therefore assumes no liability whatsoever of any
kind for the information and data accessed through the Service or for
any diagnosis or treatment made in reliance thereon. David F. McAuley, Pharm.D., R.Ph. GlobalRPh Inc. |
| Disclaimer Contact Us Privacy Policy Website Search | We comply with the HONcode standard for health trustworthy information: Verify here. Copyright © 2007 GlobalRPh Inc. |
 |
 |