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Infection
Sinusitis 

Additional Info

 Possible therapeutic alternatives
Sinusitis (Acute) symptoms < 4 weeks.

Usual duration of therapy: 10-14 days

 		 Common pathogens
Augmentin 500mg orally three times daily or 875mg twice daily  or    
Cefpodoxime (Vantin) 200-400 mg twice daily x 10-14 days.
Cefzil 250-500mg orally twice daily  or 
Ceftin (cefuroxime oral) 250mg orally twice daily  or
Bactrim DS twice daily
Severe penicillin allergy:  
Clarithromycin 500mg orally twice daily or 
Zithromax (Azithromycin)  500mg PO x 1, then 250mg PO qd x 4 days
Levofloxacin 500mg orally once daily, or moxifloxacin 400mg PO daily.
Drug resistant S.pneumo:
Levofloxacin 500mg orally once daily x 7-10 days
Chronic sinusitis (symptoms > 3 months) Common pathogens
Same as above. Surgery may be required. Consider reserving antibiotic therapy for acute flares only.
Sinusitis (Hospitalized patient) Intubated etc. Common pathogens
[Ceftazidime 1 to 2 grams IV every 8 hours + Tobramycin IV]  or  
Ciprofloxacin 400mg IV q12h or  Levofloxacin 500mg IV qd or or moxifloxacin (Avelox) 400mg once daily
Cefepime 2 grams IV every 12 hours  or  
Imipenem 500mg IV every 6 hours

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References - Infectious Disease Section
Infectious Disease References

Disclaimer
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.
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