Angiotensin II Receptor Blockers

Angiotensin II Receptor Blockers:

<Drug Comparisons>

candesartan (Atacand ®)

Supplied: 4 mg, 8 mg, 16 mg, 32 mg
Dosing: Hypertension: Oral: Initial: 16 mg once daily. Range: 4 to 32 mg once daily. Dosage must be individualized. It can be administered once or twice daily with total daily doses ranging from 8-32 mg. CHF: Oral: Initial: 4 mg once daily. Double the dose at 2-week intervals, as tolerated; target dose: 32 mg.

eprosartan mesylate (Teveten) ®

Supplied: 400 mg, 600 mg
Dosing: Hypertension: Oral: Usual initial dose is 600 mg once daily. Dosage must be individualized. Can administer once or twice daily with total daily doses of 400 to 800 mg. Limited clinical experience with doses greater than 800 mg.

irbesartan (Avapro ®):

Supplied: 75 mg, 150 mg, 300 mg
Dosing: Hypertension: Oral: 150 mg once daily ... patients may be titrated to 300 mg once daily. Note: Starting dose in volume-depleted patients should be 75 mg.

losartan (Cozaar ®):

Supplied: 25 mg, 50 mg, 100 mg
Dosing: Hypertension: Oral: Initial: 25 to 50 mg once daily. Can be administered once or twice daily with total daily doses ranging from 25 to 100 mg. Usual initial doses in patients receiving diuretics or those with intravascular volume depletion: 25 mg.

olmesartan (Benicar ®):

Supplied: 5 mg, 20 mg, 40 mg
Dosing: Hypertension: Oral: Initial: Usual starting dose is 20 mg once daily. If initial response is inadequate, may be increased to 40 mg once daily after 2 weeks. Consider lower starting dose in patients with possible volume deficits.

telmisartin (Micardis ®):

Supplied: 20 mg, 40 mg, 80 mg
Dosing: Hypertension: Oral: Initial: 40 mg once daily. Usual maintenance dose range: 20 to 80 mg per day. Patients with volume depletion should be initiated on the lower dosage with close supervision.

valsartan (Diovan ®):

Supplied: 40 mg, 80 mg, 160 mg, 320 mg
Dosing: Hypertension: Initial: 80 mg or 160 mg once daily (in patients who are not volume depleted). Dose may be increased to achieve desired effect ... maximum recommended dose: 320 mg per day.

CHF: Initial: 40 mg twice daily. Titrate dose to 80 to 160 mg twice daily, as tolerated. Maximum daily dose: 320 mg. Left ventricular dysfunction after MI: Initial: 20 mg twice daily. Titrate dose to target of 160 mg twice daily as tolerated.

Decreased renal perfusion

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David F. McAuley, Pharm.D., R.Ph. GlobalRPh Inc.

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