Absolute Neutrophil Count

Total WBCs:   
How are the Segs and Bands reported
Total Segs (segmented neutrophils)
Total Bands

Background Info

(1) Segs and bands reported as a percentage: 
WBC * ((segs / 100) + (bands / 100))

 (2) Segs and bands reported in total numbers:
ANC = (segs + bands) x 1000

Neutrophils (aka polymorphonuclear cells, PMNs, granulocytes, segmented neutrophils,  or segs) fight against infection and represent a subset of the white blood count. Neutropenia by definition is an ANC below 1800/mm3 (some sources use a lower value).  

Absolute neutrophil count (ANC) of 1000-1800:
Most patients will be given chemotherapy in this range.
Risk of infection is considered low.

Mild neutropenia - Absolute neutrophil count (ANC) of 500-1000
Carries with it a moderate risk of infection.

Absolute neutrophil count (ANC) of less than 500:
neutropenia - high risk of infection. Remember that a reduced WBC is known as leukopenia.

The WBC consists of the following (differential):
Lymphocytes: 20-40%
Neutrophils: 50-60%
Basophils: 0.5-2%
Eosinophils: 1-4%
Monocytes: 2-9% (average: 4%).
ANC = Total WBC x (% "Segs" + % "Bands") 
Equivalent to: WBC x ((Segs/100) + (Bands/100))

The ANC refers to the total number of neutrophil granulocytes present in the blood. 

Normal value: geq 1500 cells/mm3.
Mild neutropenia: geq1000 - <1500/mm3.
Moderate neutropenia: geq500 - <1000/mm3.
Severe neutropenia: < 500/mm3.

Ayalew Tefferi, MD, ed. Primary Hematology. Totowa, NJ: Humana Press, 2001.


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