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Absolute Neutrophil Count

Total WBCs:   
Total Segs (neutrophils)
Total Bands: 

Background Info

Equations: 
(1) Segs and bands reported as a percentage: 
WBC * ((segs / 100) + (bands / 100))

 (2) Segs and bands reported in total numbers:
WBC * (segs + bands)

Neutrophils (aka polymorphonuclear cells, PMNs, granulocytes, segmented neutrophils,  or segs) fight against infection and represent a subset of the white blood count. Neutropenia by definition is an ANC below 1800/mm3 (some sources use a lower value).  

Absolute neutrophil count (ANC) of 1000-1800:
Most patients will be given chemotherapy in this range.
Risk of infection is considered low.

Mild neutropenia - Absolute neutrophil count (ANC) of 500-1000
Carries with it a moderate risk of infection.

Absolute neutrophil count (ANC) of less than 500:
Severe
neutropenia - high risk of infection. Remember that a reduced WBC is known as leukopenia.

The WBC consists of the following (differential):
Lymphocytes: 20-40%
Neutrophils: 50-60%
Basophils: 0.5-2%
Eosinophils: 1-4%
Monocytes: 2-9% (average: 4%).
ANC = Total WBC x (% "Segs" + % "Bands") 
Equivalent to: WBC x ((Segs/100) + (Bands/100))

The ANC refers to the total number of neutrophil granulocytes present in the blood. 

Normal value: geq 1500 cells/mm3.
Mild neutropenia: geq1000 - <1500/mm3.
Moderate neutropenia: geq500 - <1000/mm3.
Severe neutropenia: < 500/mm3.




Reference
Ayalew Tefferi, MD, ed. Primary Hematology. Totowa, NJ: Humana Press, 2001.

Disclaimer

All calculations must be confirmed before use. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.   Read the disclaimer
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