| AMPHOTERICIN-B |
| Usual
Diluents |
| D5W |
| Standard
Dilutions [Amount of drug]
[Infusion volume] [Infusion rate] |
Dilute each
'mg' of drug with 10 ml.
[1 mg/
10 ml ] [4 - 6 hours]
Central line: 0.25 mg/ml (higher
concentrations possible)
|
|
| Stability
/ Miscellaneous |
EXP: 1 Day
(RT). Label:
REFRIGERATE. Precipitates in normal saline or solution with
bacteriostatic agent.
Test dose: 1 mg/20 ml D5W over 10-30 min. Monitor
Temp, pulse, RR and BP q30min x 4 hours.
Dosing: initially 0.25 to
0.3 mg/kg (possibly up to 0.5 mg/kg for life threatening infections).
Increase as tolerated on the following days to 0.5 to 1.0 mg/kg/day or
1.5 mg/kg qod. If central line is used, may increase concentration up to
0.25 mg/ml.
Bladder irrigation: add 10-50mg to 1000ml sterile water.
Instill 200-300ml into bladder then clamp off for 60-90min, then allow
bladder to drain-then repeat. Continue treatment for 2-5 days. |
| |
|
|
|
|
