DOSAGE AND ADMINISTRATION
Since both the 250-mg and 500-mg tablets of AUGMENTIN contain the same amount of
clavulanic acid (125 mg, as the potassium salt), two 250-mg tablets of AUGMENTIN
are not equivalent to one 500-mg tablet of AUGMENTIN; therefore, two 250-mg
tablets of AUGMENTIN should not be substituted for one 500-mg tablet of
The usual adult dose is one 500-mg tablet of AUGMENTIN every 12 hours or one
250-mg tablet of AUGMENTIN every 8 hours. For more severe infections and
infections of the respiratory tract, the dose should be one 875-mg tablet of
AUGMENTIN every 12 hours or one 500-mg tablet of AUGMENTIN every 8 hours.
Pediatric patients weighing 40 kg or more should be dosed according to the adult
Due to the different amoxicillin to clavulanic acid ratios in the 250-mg tablet
of AUGMENTIN (250/125) versus the 250-mg chewable tablet of AUGMENTIN
(250/62.5), the 250-mg tablet of AUGMENTIN should not be used until the
pediatric patient weighs at least 40 kg or more.
AUGMENTIN may be taken without regard to meals; however, absorption of
clavulanate potassium is enhanced when AUGMENTIN is administered at the start of
a meal. To minimize the potential for gastrointestinal intolerance, AUGMENTIN
should be taken at the start of a meal.
[CRCL >30 ]: no change
[10-30 ]: 250-500 mg q12h. Do not use the 875 mg tablet.
[<10 ml/min]: 250-500 mg q24h. Do not use the 875 mg tablet.
Patients with impaired renal function do not generally require a
reduction in dose unless the impairment is severe. Severely impaired
patients with a glomerular filtration rate of <30 mL/min. should not
receive the 875-mg tablet. Patients with a glomerular filtration rate of
10 to 30 mL/min. should receive 500 mg or 250 mg every 12 hours,
depending on the severity of the infection. Patients with a less than 10
mL/min. glomerular filtration rate should receive 500 mg or 250 mg every
24 hours, depending on severity of the infection.
250/125 to 500/125mg q24h. Give additional dose after dialysis.
Hemodialysis patients should receive 500 mg or 250 mg every 24 hours,
depending on severity of the infection. They should receive an
additional dose both during and at the end of dialysis.
National Institutes of Health, U.S. National Library of Medicine,
DailyMed Database. Provides access to the latest drug monographs submitted to the
Food and Drug Administration (FDA). Please review the latest applicable package insert for
additional information and possible updates. A local search
option of this data can be found here.
The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical
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