Aminophylline

Usual Diluents

D5W,  NS

Standard Dilutions

Loading dose:   [0 - 250mg] [50ml] [30 minutes] or   [251-500 mg] [ 100 ml ] [30 minutes]

Continuous infusion: [500 mg] [500 ml] [Titrate]

Fluid Restricted: [500 mg] [250 ml] [Titrate]

Stability / Miscellaneous

EXP: 1 day (RT).   Maximum rate: 25 mg/min.  IV loading: 5 mg/kg TBW based on theophylline or 6 mg/kg based on aminophylline.  Previous therapy: [Loading dose= 0.5 L/kg TBW x (desired level - current level)] IV maintenance dose based on IBW and theophylline. For aminophylline dosing divide result by 0.8.  Adult non-smoker: 0.4 mg/kg/hr  Adult (smoker): 0.7 mg/kg/hr  Elderly (smoker): 0.5 mg/kg/hr  Elderly (non-smoker)/ CHF/ Liver dx: 0.2 mg/kg/hr.  Obtain level 24-48 hours after initiation of tx.  Average half-life: 3 to 12 hours. Vd: 0.5 L/kg Therapeutic range: 5-20 mcg/ml.