Allopurinol
Zyloprim ® - Renal dosing |
| Usual
Dosing (Adults) |
|
Gout: initially 100mg qd. Increase by 100mg/day q7days, titrate to desired uric acid level. Usual range: (Mild gout): 200-300mg/day. Moderate-severe: 400-600mg/day. Maximum dose/day: 800mg
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|
| Renal
Dosing |
| Oral:
|
[>80
ml/min]: Usual dose
[60 - 80]: 200-250 mg daily
[40 - 60]: 150 - 200mg daily
[20 - 40]: 100 - 150mg daily
[10 - 20]: 100mg q24
[<10 ml/min]: 100 mg q24-48h
Alternatively:
[>50 ml/min]: No changes
[20-50]: 100-300mg q24h.
[10-20]: 100-200mg q24h.
[<10]: 100mg q24-48h.
|
| IV:
|
[10
- 20 ml/min]: Administer 200 mg/day.
[3 - 10 ml/min]: Administer 100 mg/day.
[<3 ml/min]: Administer 100 mg/day at extended intervals.
|
|
| Hemodialysis |
100mg q24-48h (give dose after dialysis on dialysis
days.)
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