Aldosterone Antagonists

eplerenone  (Inspra ®)  

CHF: 25mg orally once daily. May increase to max dose of 50mg once daily after 4 weeks. HTN: 50mg orally once daily. May increase to max dose of 50mg twice daily after 4 weeks. Contraindicated in males with SCR>2.0 mg/dl or females with SCR >1.8 mg/dl.
[Supplied: 25 mg, 50 mg tablets]

spironolactone  (Aldactone ®):

Initial dosage (Adults):
Oral:
Edema: 25 to 200 mg/day in 1-2 divided doses.
Hypertension: 25-50 mg/day in 1-2 divided doses.
Diagnosis of primary aldosteronism: 100-400 mg/day in 1-2 divided doses.
Hirsutism in women (unlabeled use): 50-200 mg/day in 1-2 divided doses.
CHF, severe:  Usual: 12.5 to 25 mg/day. 

[Supplied: 25, 50, 100mg tablets]


 

Disclaimer

Listed dosages are for - Adult patients ONLY. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. GlobalRPH does not directly or indirectly practice medicine or provide medical services and therefore assumes no liability whatsoever of any kind for the information and data accessed through the Service or for any diagnosis or treatment made in reliance thereon.

David F. McAuley, Pharm.D., R.Ph.  GlobalRPh Inc.