Aldosterone Antagonists

eplerenone (Inspra ®)

CHF: 25mg orally once daily. May increase to max dose of 50mg once daily after 4 weeks. HTN: 50mg orally once daily. May increase to max dose of 50mg twice daily after 4 weeks. Contraindicated in males with SCR>2.0 mg/dl or females with SCR >1.8 mg/dl.
[Supplied: 25 mg, 50 mg tablets]

spironolactone (Aldactone ®):

Initial dosage (Adults):
Oral:
Edema: 25 to 200 mg/day in 1-2 divided doses.
Hypertension: 25-50 mg/day in 1-2 divided doses.
Diagnosis of primary aldosteronism: 100-400 mg/day in 1-2 divided doses.
Hirsutism in women (unlabeled use): 50-200 mg/day in 1-2 divided doses.
CHF, severe: Usual: 12.5 to 25 mg/day.

[Supplied: 25, 50, 100mg tablets]

Disclaimer

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David F. McAuley, Pharm.D., R.Ph. GlobalRPh Inc.

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