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Acyclovir
Zovirax ®
Usual Dosing (Adults)

Mucocutaneous herpes simplex: IV: 5 mg/kg/dose every 8 hours x 5-10 days.   
Encephalitis
: 10mg/kg/dose IV every 8 hours.   
Primary
HSV infection-genital (Oral therapy): 200mg every 4 hours while awake (5 times/day) or 400mg orally three times daily for 10 days.  
Recurrent
genital: 400mg orally three times daily for  5 days. 
Herpes Zoster:
800mg orally every 4 hours while awake (5 times/ day)  for  7 days. If severe give 10-12 mg/kg IV every 8 hours x 7-14 days.   
Chronic suppression
(genital herpes): 400mg orally twice daily.  

Renal Dosing
Oral:
Genital herpes therapy:
[>/= 10]: Usual dose
[<10 ml/min]: 200mg q12h

Genital herpes suppression/prophylaxis:
[>/= 10]: Usual dose
[<10 ml/min]:  200mg q12h

Herpes zoster:
[>25 ml/min]: Usual dose
[10-25]: 800mg q8h
[<10 ml/min]:  800mg q12h

IV:

[>50 ml/min]:  No change
[30-50]: 5-10mg/kg q12h
[10-30]: 5-10mg/kg q24h
[<10 ml/min]: 2.5 to 5mg/kg q24h

Hemodialysis
IV: 2.5 - 5 mg/kg IV q24h (give dose after dialysis on dialysis days).
Oral: See above for <10 ml/min.


 

 

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