Acyclovir
Zovirax ® |
| Usual
Diluents |
| D5W, NS |
| Standard
Dilutions [Amount of drug]
[Infusion volume] [Infusion rate] |
[0-350
mg] [50 ml] [1 hour]
[351-700 mg] [100 ml] [1 hour]
|
|
| Stability
/ Miscellaneous |
EXP: 1 day
(RT). (Note:
conflicting data regarding estimated stability. Some studies have
reported much longer stability (3- 4 weeks), while other studies confirm
the stability indicated by the manufacturer (24 hours).
Label:
Do not refrigerate. Maximum concentration
= 7 mg/ml.
Mucocutaneous herpes simplex: IV: 5 mg/kg/dose
q8h x 5-10 days. Encephalitis: 10mg/kg/dose IV q8h. Primary HSV
infection-genital (Oral therapy): 200mg q4h while awake (5x/day) or
400mg po tid x 10 days. Recurrent genital: 400mg po tid x 5 days. Herpes
Zoster: 800mg po q4h while awake (5x/day) x 7 days. If severe give 10-12
mg/kg IV q8h x 7-14 days. Chronic suppression (genital herpes): 400mg po
bid. Zovirax ointment: apply ½" q3h (6 x/day).
Renal
Dosing: 50 - 90/ 5 to 12.4 mg/kg q8h || 10-50 / 5-12.4 mg/kg q12-24h
|| <10 / 2.5 to 6 mg/kg q24h. Alternatively: (Oral): 10-25 / dose q8h
|| <10 / dose q12h. (IV): 25-50/ 5-10mg/kg q12h || 10-25/ 5-10mg/kg
q24h || <10/ 2.5 to 5mg/kg IV q24h. || HD: dose after dialysis ||
CAPD: see < 10. |
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