Actinic keratosis (topical therapy)

Actinic keratoses (AKs) are premalignant lesions that develop only on sun-damaged skin.

declofenac  (Solaraze ®)  
Apply to lesion areas twice daily (smoothed onto the affected skin gently). Recommended duration of therapy: 60 days to 90 days. Complete healing of the lesion(s) or optimal therapeutic effect may not be evident for up to 30 days following cessation of therapy. Lesions that do not respond to therapy should be carefully re-evaluated and management reconsidered.  Appears to be significantly better tolerated than twice daily application of 5-FU, although it may be somewhat less effective.
[Supplied: Gel: 25 and 50 gram tubes. Each gram of gel contains 30 mg of diclofenac sodium.]

fluorouracil  (Efudex ®):

Superficial basal cell carcinomas: apply 5% cream/solution twice daily.

Actinic keratoses:
Carac™: Apply thin film to lesions once daily for up to 4 weeks, as tolerated.
Efudex®: Apply to lesions twice daily for 2-4 weeks; complete healing may not be evident for 1-2 months following treatment.
Fluoroplex®: Apply to lesions twice daily for 2-6 weeks
Supplied: Cream, topical:
Carac™: 0.5% (30 g).   Efudex®: 5% (25 g, 40 g).   Fluoroplex®: 1% (30 g).

Other:
1) Liquid nitrogen cryotherapy - widely utilized.
2) Chemical peels.
3) Dermabrasion.
4) Surgical (curettage) therapy.

 

Disclaimer
Listed dosages are for - Adult patients ONLY. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. GlobalRPH does not directly or indirectly practice medicine or provide medical services and therefore assumes no liability whatsoever of any kind for the information and data accessed through the Service or for any diagnosis or treatment made in reliance thereon.

David F. McAuley, Pharm.D., R.Ph.  GlobalRPh Inc.

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