Acetylcysteine Acetadote ®

Usual Diluents

D5W

Standard Dilutions   [Amount of drug]  [Infusion volume]  [Infusion rate]

Acetaminophen overdose: Adult Loading dose:  [150mg/kg] [200 ml] [15 min] Maintenance dose: [50 mg/kg] [500ml] [over 4 hrs] Followed by: [100 mg/kg] [1000ml] [over 16 hrs] Important note: in fluid restricted patients or patients <40kg: the volume of D5W used should be reduced proportionately.

Stability / Miscellaneous

Stability: 24 hours room temp.  Supplied: Acetadote injection is available as a 20% solution in 30 ml (200mg/ml) single glass vials.  Do not use previously opened vials for IV administration.See package insert for additional comments.