Chlamydophila pneumoniae

Chlamydophila pneumoniae

Background:
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Atypical Organisms
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>Chlamydophila pneumoniae Led
>Chlamydophila psittaci
>Coxiella burnetii
>Legionella species ( L. pneumophila)
>Mycoplasma pneumonia

Chlamydophila pneumoniae 

  • -(formally known as Chlamydia pneumoniae)
  • -obligate intracellular bacterium (must infect another cell to reproduce)
  • -major cause of pneumonia.
  • -small gram negative bacterium (0.2 to 1 µm).
  • -undergoes several transformations during its life cycle.
  • -categorized as an “atypical pneumonia” because its treatment and diagnosis are different from historically recognized causes, such as S. pneumoniae.

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Therapy:
Important considerations:  The choice of an agent should be based on local antimicrobial sensitivities, site of infection, cost, and comorbid conditions.   Generally, the most common agents/regimens are listed first. Adjust length of therapy based on clinical course.  Generally slow response to therapy and in some cases requires a second course of treatment.

  1. Doxycycline 100mg orally or IV twice daily x 7-10 days
  2. Azithromycin  500mg orally x 1 then 250mg  once daily for 4 days
  3. Clarithromycin 500mg orally twice daily x 7-14 days
  4. Levofloxacin 750 mg IV/PO once daily  x 7-14 days
  5. Moxifloxacin 400mg orally/IV once daily x 7-14 days
Chlamydophila pneumoniae